Biomechanical stimulations during long bones lengthening by distraction osteogenesis method have key influence on the development and formation acceleration of bone regenerate tissue in interfragmental gap of interrupted diaphysis. These physiological or artificially applied external effects with regard to their direction and size by different ways regulate the extracellular matrix synthesis of intefragmental tissue, resulting in the genesis of the relevant characteristic phenotypes of tissue structures. The study of kinetic processes of callus tissue formation and ossification with dependency on stress and strain distribution changes is performed according to various and inhomogeneous course of bone tissue formation in the callus sub-volume locations within individual characteristic phases of the healing process.
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