Residential mobility significantly influences land use, occupation of housing stock, infrastructure usage, social composition of population, real estate prices and quality of life in general. To promote sustainable urban development, it is necessary to understand the causes and consequences of residential mobility. Residential mobility is an outcome of decision-making by individual actors, typically households; therefore, it is important to understand the rationale behind their decision-making. The research presented in the paper applies random utility discrete choice models for the examination of factors that influence residential choices made by individual actors in the Prague Metropolitan Area. The research primarily focuses on transportation accessibility to employment opportunities as one of the primary residential mobility factors and examines various accessibility indicators. The resulting residential choice model allows for testing the impact of planned transportation improvements on the residential choices of individual actors. The paper concludes by discussing the potentials and constraints for the examination of residential mobility by means of discrete choice models.